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IBEx group
Imaging Brain Excitability
Principal investigator:
Dr Vincent Magloire is currently a Wellcome research fellow interested in how brain excitability is regulated and how its dysfunction leads to paroxysmal disorders (e.g. epilepsy), with a view to developing novel treatment strategies. After completing his PhD at the University of Bern, Swizterland, he moved to the UK to work with Prof. Ole Paulsen at the University of Cambridge on the cholinergic and glutamatergic modulation of cortical Up states. He then became interested in GABAergic modulation of physiological and pathological network activity such as seizures and joined the department of Clinical and Experimental Epilepsy at UCL to work with Prof. Dimitri Kullmann and Dr Ivan Pavlov. In 2019, He started his own research group within the department. Vincent is also a big fan of the outdoors and enjoys trail running and various mountain sport activities. Full CV here.
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Dr Robert Graham is a research associate. He completed his PhD in networks neuroscience at Newcastle University with Andrew Trevelyan on the role of chloride redistribution in dynamic seizure risk. In 2021, he joined us to work on investigating the mechanisms of epilepsy in focal cortical dysplasia (FCD), a congenital condition leading to a malformation of the neocortex. By combining highly detailed slice electrophysiology, and cell-resolved functional imaging of key network components in the intact brain, he aims to uncover the roles of different neuronal types to the emergence of spontaneous seizures. In addition, he is interested in the role of brain states (e.g. SWS, REM) in determining seizure risk and used a variety of optical sensors for key neuromodulators and neurotransmitters to directly study electrographically invisible mediators of network activity. Full CV here.
Qimin Wu is an undergraduate student on the UCL Neuroscience course. Qimin is interested in GABAergic interneurons and in particular neurogliaform (NGF) neurons. Qimin is using immunostaining, microscopy, chemogenetics and electrocorticogram in chronic model of epilepsy to understand whether NGF cells can be harnessed to stop seizures.
Former supervision:
Dr Amanda Almacellas Barbanoj
Dr Mikail Weston
Haoming You
Grace Budgen
Alex Garcia Garcia
Benito Maffei
Dion Weerasuriya
Maud Muller
James Scott-Solaches
Maria Grozdanova
Liberty Roskrow
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